Led by founder and managing partner Hugh Campbell, the new office is at One New York Street.
Mr Campbell will be joined in Manchester by Adam Rudd, who was previously with Gresham Private Equity, where he focused on investment in tech business such as Warrington company IESA. Before joining Gresham, Mr Rudd worked for AO.com, the recently-floated retailer, having started his career with KPMG and Brewin Dolphin.
GP Bullhound's new Manchester office is its fifth, and follows London, San Francisco, Stockholm and Berlin. It plans to seek out technology-focused businesses looking to raise funds for growth or to sell.
It recently advised Macclesfield-based CarLoan4U with its £8m fundraise.
Mr Campbell, 41, said: "We see the opportunities in the North West as being enormous, it's a key area for us as we look to expand. We are very excited to be here and look forward to making a difference to the tech community in this region and helping entrepreneurs find capital to succeed.
"We know that our blend of deal-making, research and events are a breath of fresh air for many companies and founders. Our international reach to investors and buyers in the US, continental Europe and Asia will be invaluable to those companies looking to grow and prosper on the world stage."
